1,2,3,4,5,6-Hexabromocyclohexane - CAS 1837-91-8

The compound effectively and directly inhibits JAK2 tyrosine kinase autophosphorylation and specifically inhibits ligand-dependent JAK2 activation. It has no cytotoxicity at 100 μM. A 16-hour treatment with compound (1 μM) decreases JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μM eliminates nearly all JAK2 activity.

JAK, Others

Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, Angiogenesis, Others, Stem Cells, JAK/STAT signaling

1738

C6H6Br6

557.54

BrC1C(Br)C(Br)C(Br)C(Br)C1Br

-20°C

Ice Packs

Small Compound