1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin - CAS 57653-85-7

1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin, a polychlorinated dibenzodioxin (PCDD), acts as an agonist for the aryl hydrocarbon receptor (AhR; EC50s = 5.4 and 9.3 nM at 4 and 8 h, respectively, in a reporter assay) . It has been observed to reduce antibody production against sheep red blood cells in mice at doses of 0.5 and 2 μg/kg. This compound has been detected in animal feed and in the vicinity of municipal waste incinerators.

Aryl Hydrocarbon Receptor

Immunology/Inflammation

57653-85-7

C12H2Cl6O2

390.86

ClC1=C(Cl)C=C2OC3=C(C=C(C(Cl)=C3Cl)Cl)OC2=C1Cl

-20°C

Ice Packs

Peptide