1-Hydroxy-2,3,5-trimethoxyxanthone - CAS 22804-49-5

1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) exhibits vasodilator action through an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca (2+) influx via L-type voltage-operated Ca (2+) channels. A minor contribution to HM-1's effects may stem from inhibiting protein kinase C-mediated release of intracellular Ca (2+) stores. At 1 μg/mL, HM-1 effectively inhibits osteoclast differentiation in co-cultures with mouse osteoblastic calvarial and bone marrow cells and protects mice from acute lung injury induced by lipopolysaccharide (LPS), likely by increasing IκB-α protein expression and suppressing inducible nitric oxide synthase and cyclooxygenase-II protein expression.

COX, Calcium Channel, 5-HT Receptor, IκB/IKK, NOS

Neuroscience, Metabolism, GPCR/G Protein, Membrane transporter/Ion channel, Immunology/Inflammation, NF-κB

22750

C16H14O6

302.28

COc1cc2oc3c(OC)cccc3c(=O)c2c(O)c1OC

-20°C

Ice Packs

Natural Product