10-Formyl-5,8-dideazafolic acid - CAS 61038-31-1

10-Formyl-5,8-dideazafolic acid (CB3717) is a water-soluble analog of folic acid, also known as folate. Folate is a member of the B-vitamin family, which plays a supporting role in a number of key biochemical reactions in the body, including RNA and DNA synthesis. Made up of pteridine, para-aminobenzoic acid, and glutamate, 10-Formyl-5,8-dideazafolic acid is a compound that inhibits de novo folate metabolism. It induces cell cycle arrest at phase G (1) -S, disrupts repair of cells damaged by radiation, and induces apoptosis.

DNA/RNA Synthesis

Cell Cycle/Checkpoint, DNA Damage/DNA Repair

61006

0.9604

C22H21N5O7

467.43

Nc1nc(=O)c2cc(CN(C=O)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)ccc2[nH]1

-20°C

Ice Packs

Small Compound