10-Methoxy-canthin-6-one - CAS 86293-40-5

10-Methoxy-canthin-6-one (Mtx-C) acts as a DNA damage inducer that embeds into DNA, promoting cell cycle arrest at the G2/M phase. This process triggers myeloid differentiation in acute myeloid leukemia cells (AML) and leukemia stem cells (LSC) . Differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, along with the activation of p38 MAPK. 10-Methoxy-canthin-6-one is utilized in the study of leukemia.

P38 MAPK

MAPK

86248

C15H10N2O2

250.25

O=C1C=CC2=NC=CC=3C4=CC(OC)=CC=C4N1C23

-20°C

Ice Packs

Small Compound