(±) 11 (12) -EpETE - CAS 504435-15-8

Eicosapentaenoic acid (EPA) is metabolized into epoxyeicosatetraenoic acids (EpETE) by multiple cytochrome P450 isoforms. The predominant compound of this epoxygenase pathway, (±) 17 (18) -EpETE, induces relaxation in vascular and airway smooth muscles through its action on large conductance Ca2+-activated K+ (BKCa) channels, specifically by binding to the BKα channel subunits. Another notable epoxygenase pathway derivative, (±) 11 (12) -EpETE, also generated from EPA via CYP450 activity in both in vitro and in vivo studies, has biological and physiological roles that are yet to be fully elucidated.

Others, Endogenous Metabolite

Metabolism, Others

504435-15-8

C20H30O3

318.5

C(/C=C\C/C=C\CCCC(O)=O)C1C(C/C=C\C/C=C\CC)O1

-20°C

Ice Packs

Small Compound