11β-13,14-dihydro-15-keto Prostaglandin F2α - CAS 107615-77-0

11β-13,14-Dihydro-15-keto PGF2α, a PGD2 metabolite in the 15-hydroxy PGDH pathway, is formed in human males upon infusion or inhalation of tritiated PGD2, with peak plasma levels of both 11β-PGF2α and 11β-13,14-dihydro-15-keto PGF2α observed within 10 minutes. In human lung homogenates, PGD2 is metabolized firstly to 11β-PGF2α and subsequently to 11β-15-keto-PGF2α in the presence of NAD+, but not to 11β-13,14-dihydro-15-keto PGF2α. Conversely, guinea pig liver and kidney homogenates can metabolize PGD2 to 11β-13,14-dihydro-15-keto PGF2α via 11β-PGF2α, with both NAD+ and NADP+ being requisite for this conversion.

Others, Endogenous Metabolite

Others, Metabolism

107615-77-0

C20H34O5

354.5

C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](CCC(CCCCC)=O)[C@@H](O)C[C@@H]1O

-20°C

Ice Packs

Small Compound