11-cis Retinal - CAS 564-87-4

11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. When 11-cis retinal absorbs a photon of light, it isomerizes to form all-trans retinal beginning the phototransduction cycle, which is the basis for mammalian vision. A G121L mutation in opsin allows 11-cis retinal to bind as a partial agonist and activate rhodopsin in the absence of light. In a moth model of carotenoid deficiency-induced low visual sensitivity, 11-cis retinal application to compound eyes restored visual sensitivity almost completely.

Others, Endogenous Metabolite

Metabolism, Others

473

C20H28O

284.443

C/C(/C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C)=C\C=O |c:9|

-20°C

Ice Packs

Small Compound