119-23 - CAS 2953044-98-7

119-23 is an ionizable cationic lipid frequently utilized in the preparation of lipid nanoparticles (LNPs) for in vivo mRNA delivery. Lipid nanoparticles that include 119-23 and encapsulate mRNA reporter molecules demonstrate a higher transfection efficiency in mouse muscle compared to LNPs containing SM-102 or DLin-MC3-DMA. Additionally, the accumulation of 119-23-containing LNPs in immune cells within the liver and spleen of mice is significantly greater than that of LNPs with SM-102. Furthermore, LNPs containing 119-23 and encoding human erythropoietin (hEPO) mRNA can elevate serum hEPO levels in mice.

2952939

C58H105N3O4

908.47

N(C(C(N(C(CCCCCCC/C=C\CCCCCCCC)=O)CCCN(C)C)CCCCCOC(CCCCCCC/C=C\CCCCCCCC)=O)=O)C12CC3CC(C1)CC(C2)C3

-20°C

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