(±) 12-HEPE - CAS 81187-21-5

(±) 12-HEPE is produced by non-enzymatic oxidation of EPA, resulting in equal amounts of 12 (S) -HEPE and 12 (R) -HEPE. The biological activity of (±) 12-HEPE is likely mediated by one of the individual isomers, primarily the 12 (S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with an IC50 of 24 μM, similar to 12-HETE (IC50 = 25 μM), and both compounds also inhibit U46619-induced contraction of rat aorta with IC50 values between 8.6-8.8 μM. [1][2]

Prostaglandin Receptor, Others

Others, Immunology/Inflammation, GPCR/G Protein

81161

C20H30O3

318.457

CC\C=C/C\C=C/CC(O)\C=C\C=C/C\C=C/CCCC(O)=O

-20°C

Ice Packs

Small Compound