12 (R) -HETE - CAS 82337-46-0

Biosynthesis of 12 (R) -HETE in invertebrates is via lipoxygenation of arachidonic acid . In mammals, 12 (R) -HETE can be produced by 12 (R) -LOs and also by CYP450 oxidation. The activity of 12 (R) -HETE in mammals is predominantly proinflammatory. 12 (R) -HETE exhibits dose-dependent leukocyte chemotaxis at concentrations as low as 100 nM, and lowers intraocular pressure in rabbits.

Others, Aryl Hydrocarbon Receptor, ATPase

Immunology/Inflammation, Membrane transporter/Ion channel, Others

82291

C20H32O3

320.47

C(\[C@@H](C/C=C\CCCCC)O)=C/C=C\C/C=C\CCCC(O)=O

-20°C

Ice Packs

Small Compound