12 (S) -HEPE - CAS 116180-17-7

12 (S) -HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12 (S) -HEPE to 12 (S),20-diHEPE, while stimulated neutrophils produce 5 (S),12 (S) -HEPE via the 5-lipoxygenase pathway. The competitive action of 12 (S) -HEPE with arachidonic acid as a substrate for 5-LO in leukotriene formation may underlie the anti-inflammatory potential of ω-3 fatty acids.

Lipoxygenase, Others, Leukotriene Receptor

Metabolism, GPCR/G Protein, Others

116156

C20H30O3

318.45

C(\[C@H](C/C=C\C/C=C\CC)O)=C/C=C\C/C=C\CCCC(O)=O

-20°C

Ice Packs

Small Compound