12 (S) -HETrE - CAS 72710-10-2

12 (S) -HETrE is an endogenous metabolite produced by oxidation of ω-6 PUFA dihomo-γ-linolenic acid (DGLA) by 12-lipoxygenase (12-LOX) in platelets, which acts on Gαs-coupled G-protein-coupled receptors, has antithrombotic properties, and has potential therapeutic use in cardiovascular disease. 12 (S) -HETrE is reported to inhibit agonist-mediated platelet activation (IC50 = 40 μM), α granule secretion, integrin αIIbβ3 activation, Rap1 activation, and thrombin-induced clot retraction in vitro.

Integrin, Others, Endogenous Metabolite, PKA

Metabolism, Cytoskeletal Signaling, Others, Tyrosine Kinase/Adaptors

72698

C20H34O3

322.48

C(\[C@H](C/C=C\CCCCC)O)=C/C=C\CCCCCCC(O)=O

-20°C

Ice Packs

Small Compound