12 (S) -HpETE - CAS 71774-10-2

12 (S) -HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LOE. 12 (S) -HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex.

DNA/RNA Synthesis, Endogenous Metabolite, Others

Others, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Metabolism

71762

C20H32O4

336.47

[C@@H](/C=C/C=C\C/C=C\CCCC(O)=O)(C/C=C\CCCCC)OO

-20°C

Ice Packs

Small Compound