12R-LOX-IN-1 - CAS 857758-13-5

12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 μM, is an inhibitor of 12R-LOX. It suppresses hyperproliferation and colony formation in Imiquimod-induced psoriatic keratinocytes, and reduces levels of reactive oxygen species, Ki67, IL-17A, TNF-α, and IL-6. This compound has utility in antipsoriatic research [1].

Others, DNA/RNA Synthesis

Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Others

857758-13-5

C15H11NO2

237.25

OC=1C=CC=2N=C(C=CC2C1)C=3C=CC=CC3O

-20°C

Ice Packs

Small Compound