(±) 13,14-EDT - CAS 355016-19-2

(±) 13,14-EDT, an oxylipin metabolite derived from adrenic acid through the cytochrome P450 (CYP) pathway, acts as a potent activator of large-conductance calcium-activated potassium channels (KCa1.1/BK) in isolated rat coronary small arterial smooth muscle cells at 50 nM, promoting dilation. Additionally, it induces arteriole dilation in isolated porcine samples with an EC50 of 12 pM and relaxes isolated bovine coronary arteries previously contracted by TP receptor agonist U-46619.

Drug Metabolite, Others

Metabolism, Others

355016-19-2

C22H36O3

348.5

OC(CCCCC/C=C\C/C=C\C[C@@H]1[C@@H](O1)C/C=C\CCCCC)=O

-20°C

Ice Packs

Small Compound