(±) 14 (15) -EET - CAS 197508-62-6

(±) 14 (15) -EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1], [2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±) 14 (15) -EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM) .[4] It reduces myocardial infarct size as a percentage of the area at risk in a canine model of ischemia-reperfusion injury induced by left anterior descending coronary artery (LAD) occlusion when administered at a dose of 0.128 mg/kg prior to occlusion or reperfusion.[5]

Others

Others

197508-62-6

C20H32O3

320.473

CCCCCC1OC1C\C=C/C\C=C/C\C=C/CCCC(O)=O

-20°C

Ice Packs

Small Compound