(±) 14-HDHA - CAS 87042-40-8

(±) 14-HDHA is a hydroxydocosahexaenoic acid, an oxidized metabolite of DHA generated intracellularly by enzymatic or non-enzymatic reactions, is one of the specific substrates of 15-PGDH and can be further oxidized to the anti-inflammatory 14-oxoDHA, and in primary alveolar macrophages, 14-HDoHE itself significantly inhibits LPS-induced IL-6 mRNA expression in primary alveolar macrophages, which may be relevant to inflammatory diseases such as asthma.

Drug Metabolite, Endogenous Metabolite

Metabolism

86994

C22H32O3

344.49

C(\C(C/C=C\C/C=C\CC)O)=C/C=C\C/C=C\C/C=C\CCC(O)=O

-20°C

Ice Packs

Small Compound