1400W - CAS 180001-34-7

1400W is a slow, tight-binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a K_d value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells and reduces the generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation [1] [2].

Apoptosis, NO Synthase

Apoptosis, Immunology/Inflammation

180001-34-7

C10H15N3

177.25

N=C(NCC=1C=CC=C(C1)CN)C

-20°C

Ice Packs

Small Compound