14S (15R) -EET methyl ester - CAS 110901-52-5

14S (15R) -EET methyl ester, an oxylipin derived from arachidonic acid through cytochrome P450 metabolism, demonstrates specific biological activities. It exhibits affinity for isolated guinea pig monocytes, evidenced by a competitive binding assay with a Ki value of 612.5 nM using [3H]14 (15) -EET. This compound notably enhances the dilation of precontracted isolated canine epicardial arterioles (EC50= 4 pM) and denuded porcine subepicardial arterioles (EC50= 3 pM), indicating potent vasodilatory effects. Unlike its isomer 14R (15S) -EET, 14S (15R) -EET methyl ester does not inhibit COX activity in enzyme assays or affect isolated platelets, highlighting its distinct functional profile.

Others, Drug Metabolite

Metabolism, Others

110901-52-5

C21H34O3

334.49

C(/C=C\C/C=C\C/C=C\CCCC(OC)=O)[C@H]1[C@@H](CCCCC)O1

-20°C

Ice Packs

Small Compound