15-deoxy-Δ12,14-Prostaglandin D2 - CAS 85235-11-6

15-deoxy-Δ12,14-Prostaglandin D2 (15-deoxy-Δ12,14-PGD2) is a PGD2 metabolite functioning as an agonist for the PGD2 receptor 2 (DP2), with a binding affinity (Ki) of 50 nM for the mouse DP2 receptor expressed in HEK293 cell membranes. It activates eosinophils with an EC50 of 8 nM and enhances the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ), initiating PPARγ-mediated transcription at 5 μM concentration. Furthermore, it exhibits cytotoxicity towards L1210 murine leukemia cells with an IC50 of 0.3 μg/ml and displays weaker inhibition of ADP-induced platelet aggregation than PGD2, with an IC50 of 320 ng/ml.

Others, Prostaglandin Receptor, Endogenous Metabolite, PPAR, Src

Immunology/Inflammation, Others, GPCR/G Protein, DNA Damage/DNA Repair, Tyrosine Kinase/Adaptors, Metabolism, Angiogenesis

30437795

C20H30O4

334.456

CCCCC\C=C\C=C1/[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O

-20°C

Ice Packs

Small Compound