15-keto Latanoprost (free acid) - CAS 369585-22-8

15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals and is a common minor impurity in commercial preparations of the bulk drug compound. Although much less potent than latanoprost, 15-keto Latanoprost can still produce a small but measurable decrease (1 mm Hg) in intraocular pressure in normal cynomolgus monkeys at a dose of 1 μg/eye. It also acts as a miotic in normal cats, causing an 8 mm Hg reduction in pupillary diameter at 5 μg/eye, though it is not as potent as many other F-type prostaglandins, such as prostaglandin F2α, which achieves the same effect at less than 1 μg/eye.

Others, Drug Metabolite

Others, Metabolism

369555

C23H32O5

388.5

C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](CCC(CCC2=CC=CC=C2)=O)[C@H](O)C[C@@H]1O

-20°C

Ice Packs

Small Compound