15-LOX-1 inhibitor 1 - CAS 2349374-37-2

9c (i472) is an inhibitor of 15-lipoxygenase-1 (15-LO-1; IC50 = 0.19 μM) .1 It decreases LPS- and IFN-γ-induced NF- B activity in RAW-Blue cells when used at concentrations of 0.2, 1, and 5 μM. 9c (i472) reduces LPS- and IFN-γ-induced increases in Nos2 expression and lipid peroxidation in RAW 264.7 cells when used at a concentration of 5 μM.

Lipoxygenase, Others

Others, Metabolism

2349335

C22H21ClN2O4

412.87

CCOC(=O)c1[nH]c2cc(Cl)ccc2c1\C=C\C(=O)NCc1ccccc1OC

-20°C

Ice Packs

Small Compound