15-Methoxypinusolidic acid - CAS 769928-72-5

15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methoxypinusolidic acid suppresses adipocyte differentiation through the inhibition of PPARgamma-dependent adipogenic gene expression.15-Methoxypinusolidic acid attenuates glutamate-induced excitotoxicity via stabilization of [Ca2+]i homeostasis and suppression of oxidative stress possibly through the actions on the NMDA receptors.15-Methoxypinusolidic acid induced apoptosis in murine microglial cells, presumably via inhibition of the cell cycle progression.

ERK, NMDAR, COX, JNK, p38 MAPK, NF-κB, IL Receptor, NOS, Calcium Channel, Others, PPAR, iGluR

Membrane transporter/Ion channel, Others, NF-κB, DNA Damage/DNA Repair, Immunology/Inflammation, Metabolism, Neuroscience, MAPK

769851

C21H30O5

362.46

COC1OC(=O)C(CC[C@H]2C(=C)CC[C@@H]3[C@]2(C)CCC[C@]3(C)C(O)=O)=C1

-20°C

Ice Packs

Natural Product