15 (R) -15-methyl Prostaglandin F2α - CAS 35864-81-4

15 (R) -15-methyl PGF2α, a metabolically stable analog of PGF2α, is an inactive, prodrug PGF agonist intended for activation by gastric acid through oral administration. This transformation involves acid-catalyzed epimerization that converts 15 (R) -15-methyl PGF2α into its active counterpart, the 15 (S) -isomer. Upon conversion, the 15 (S) -isomer has been shown to induce luteolysis in rhesus monkeys following an approximately 12 mg/animal dosage, a response not observed with the 15 (R) -isomer.

Others, Prostaglandin Receptor

Immunology/Inflammation, Others, GPCR/G Protein

35864-81-4

C21H36O5

368.514

CCCCC[C@@](C)(O)\C=C\[C@H]1[C@H](O)C[C@H](O)C1C\C=C/CCCC(O)=O

-20°C

Ice Packs

Small Compound