15 (S) -Latanoprost - CAS 145773-22-4

15 (S) -Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15 (S) -latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 μg dose of 15 (S) -latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys. 15 (S) -Latanoprost is a potential impurity in most commercial preparations of the latanoprost bulk drug product.

Others, Prostaglandin Receptor

Others, Immunology/Inflammation, GPCR/G Protein

145747

C26H40O5

432.59

C(/C=C\CCCC(OC(C)C)=O)[C@@H]1[C@@H](CC[C@@H](CCC2=CC=CC=C2)O)[C@H](O)C[C@@H]1O

-20°C

Ice Packs

Small Compound