(±) 16-HETE - CAS 128914-46-5

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±) 16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16 (R) -HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16 (S) -HETE does not affect perfusion pressure. At a concentration of 2 μM the (S) -enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R) -isomer has negligible effects on ATPase activity.

Others, ATPase

Others, Membrane transporter/Ion channel

128914-46-5

C20H32O3

320.473

CCCCC(O)\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

-20°C

Ice Packs

Small Compound