16 (R) -AFP 07 free acid - CAS 773825-80-2

Prostaglandin I2 is an unstable prostaglandin compound that inhibits platelet aggregation and induces vasodilation in the pulmonary vasculature via the "I prostanoid" (IP) receptor. AFP 07, a 7,7-difluoroprostacyclin derivative, serves as a selective and potent agonist for the IP receptor (Ki=0.561 nM) . It exhibits weaker affinity for EP receptors, with a Ki value of > 100 nM for EP1-3 and > 10 nM for EP4. The compound 16 (R) -AFP 07 free acid is an enantiomer of AFP 07. Its biological properties, particularly those involving IP and EP receptors, are yet to be fully assessed.

Prostaglandin Receptor

GPCR/G Protein, Immunology/Inflammation

773743

C22H30F2O5

412.47

C(=C/[C@@H]([C@H](CC#CCC)C)O)\[C@@H]1[C@@]2([C@@](O/C(=C\CCCC(O)=O)/C2(F)F)(C[C@H]1O)[H])[H]

-20°C

Ice Packs

Small Compound