16 (R) -Iloprost - CAS 74843-13-3

Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP1 receptors with a Ki value of 11 nM. Most preparations of iloprost contain 16 (S) and 16 (R) stereoisomers. 16 (R) -Iloprost inhibits platelet aggregation with an IC50 value of 65 nM.

Others, Prostaglandin Receptor

Immunology/Inflammation, GPCR/G Protein, Others

74827

C22H32O4

360.49

C(=C/[C@H]([C@@H](CC#CC)C)O)\[C@@H]1[C@@]2([C@@](C/C(=C\CCCC(O)=O)/C2)(C[C@H]1O)[H])[H]

-20°C

Ice Packs

Small Compound