16 (S) -Iloprost - CAS 74843-14-4

Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP1 receptors with a Ki value of 11 nM. Most preparations of iloprost contain 16 (S) and 16 (R) stereoisomers. 16 (S) -Iloprost potently inhibits platelet aggregation with an IC50 value of 3.5 nM.

Prostaglandin Receptor, Others

GPCR/G Protein, Others, Immunology/Inflammation

74825

C22H32O4

360.49

C(=C/[C@H]([C@H](CC#CC)C)O)\[C@@H]1[C@@]2([C@@](C/C(=C\CCCC(O)=O)/C2)(C[C@H]1O)[H])[H]

-20°C

Ice Packs

Small Compound