17-Demethoxy-reblastatin - CAS 299173-64-1

17-Demethoxy-reblastatin (17-DR) acts as an inhibitor of heat shock protein 90 (Hsp90) . It suppresses the proliferation of HepG2 and SMMC7721 cancer cells, diminishes colony formation, and triggers apoptosis via a mitochondria and caspase-mediated pathway.

HSP, Apoptosis

Cytoskeletal Signaling, Apoptosis, Metabolism

299108

C28H42N2O7

518.64

CO[C@H]1CC\C=C(C)/C(=O)NC2=CC(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)\C=C(C)\[C@H]1OC(N)=O)=CC(O)=C2

-20°C

Ice Packs

Small Compound