17-oxo-4 (Z),7 (Z),10 (Z),13 (Z),15 (E),19 (Z) -Docosahexaenoic Acid - CAS 1233715-28-0

17-oxo-4 (Z),7 (Z),10 (Z),13 (Z),15 (E),19 (Z) -Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM) .

PPAR, Nrf2, Others

Others, Immunology/Inflammation, DNA Damage/DNA Repair, Metabolism

1233687

C22H30O3

342.479

CC\C=C/CC(=O)\C=C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O

-20°C

Ice Packs

Small Compound