17-phenyl trinor Prostaglandin F2α diethyl amide - CAS 1176637-26-5

17-Phenyl trinor Prostaglandin F2αdiethyl amide (17-phenyl trinor PGF2αdiethyl amide) is a Prostaglandin F2α (PGF2α) analog characterized by the substitution of the C-1 carboxyl group with an N-diethyl amide. Prostaglandin (PG) esters and N-ethyl amides have demonstrated ocular hypotensive properties, with N-ethyl amides introduced as alternative options for PG hypotensive prodrugs. Studies indicate that both bovine and human corneal tissues can convert N-ethyl amides of various PGs into their free acid forms at a rate of approximately 2.5 μg/g corneal tissue/hr. However, dialkyl amides like 17-phenyl trinor PGF2αdiethyl amide resist conversion by corneal amidase, showing no detectable transformation into free acids. This characteristic suggests their potential as valuable investigative tools for assessing the intrinsic intraocular hypotensive activities of PG amides.

Others, Prostaglandin Receptor

Others, GPCR/G Protein, Immunology/Inflammation

1176637-26-5

C27H41NO4

443.6

C(=C/[C@H](CCC1=CC=CC=C1)O)\[C@@H]2[C@@H](C/C=C\CCCC(N(CC)CC)=O)[C@@H](O)C[C@H]2O

-20°C

Ice Packs

Small Compound