17 (R) -Resolvin D1 methyl ester - CAS 937738-64-2

17 (R) -Resolvin D1 (17 (R) -RvD1) is an aspirin-triggered epimer of RvD1 that equivalently inhibits human polymorphonuclear leukocyte migration across the endothelium (EC50= ~30 nM), a precursor to acute inflammation. Unlike RvD1, it resists rapid degradation by eicosanoid oxidoreductases. In a mouse peritonitis model, 17 (R) -RvD1 dose-dependently reduces leukocyte infiltration, achieving up to a 35% decrease with a 100 ng dose. Additionally, its methyl ester derivative, designed to enhance its pharmacokinetic and distribution properties as a more lipophilic prodrug, can be converted back into the active acid form by intracellular esterases.

Others, Endogenous Metabolite

Others, Metabolism

937738-64-2

C23H34O5

390.5

[C@@H]([C@@H](/C=C/C=C/C=C\C=C\[C@@H](C/C=C\CC)O)O)(C/C=C\CCC(OC)=O)O

-20°C

Ice Packs

Small Compound