17 (R) -Resolvin D3 - CAS 1427475-53-3

17 (R) -Resolvin D3 (17 (R) -RvD3) is an aspirin-triggered epimer of resolvin D3, produced from docosahexaenoic acid (DHA) through the action of COX-2 in the presence of aspirin, via a 17 (R) -hydroperoxy DHA (17 (R) -HDHA) intermediary. Identified in mouse inflammatory exudates, 17 (R) -RvD3 notably inhibits the transmigration of isolated human polymorphonuclear cells (PMNs) and fosters the efferocytosis of apoptotic PMNs by macrophages. Furthermore, in a mouse model of zymosan-induced peritonitis, 17 (R) -RvD3 administration (10 ng/animal) significantly curtails neutrophil infiltration into the peritoneal cavity and modulates cytokine levels by reducing IL-6 and increasing IL-10 in the inflammatory exudate. It engages GPR32, evidenced by activation in a β-arrestin reporter assay and augments phagocytosis more effectively in CHO cells overexpressing GPR32 compared to controls. Additionally, 17 (R) -RvD3 enhances the clearance of etoposide-induced tumor cell debris by monocyte-derived macrophages in H460 human lung carcinoma.

Drug Metabolite, Others

Metabolism, Others

1427475-53-3

C22H32O5

376.49

C([C@H](/C=C/C=C/C=C\[C@H](CCC(O)=O)O)O)/C=C\C=C\[C@@H](C/C=C\CC)O

-20°C

Ice Packs

Small Compound