17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α - CAS 294856-01-2

A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.1,2,3Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.417-trifluoromethylphenyl-13,14-dihydro trinor PGF2αbears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+) -fluprostenol isopropyl ester) . As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2αwould act very much like the free acid of latanoprost.

Prostaglandin Receptor, Others

Others, Immunology/Inflammation, GPCR/G Protein

294856-01-2

C24H33F3O5

458.518

O[C@H](CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O)CCc1cccc(c1)C(F)(F)F

-20°C

Ice Packs

Small Compound