17R (18S) -EpETE - CAS 725246-18-4

17R (18S) -EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R (18S) -EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium current amplitude by 15-fold in isolated rat cerebral artery vascular smooth muscle cells (VSMCs) at +60 mV when used at a concentration of 50 nM.2It has negative chronotropic effects in isolated neonatal rat cardiomyocytes (NRCMs; EC50= ~1-2 nM) and prevents calcium-induced increases in the spontaneous beating of NRCMs.3,4

Calcium Channel, Others

Membrane transporter/Ion channel, Metabolism, Others

725224

C20H30O3

318.457

CC[C@@H]1O[C@@H]1C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

-20°C

Ice Packs

Small Compound