19,20-Epoxycytochalasin D - CAS 191349-10-7

19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M. It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 &#181M, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 &#181M.

Parasite, Others, Endogenous Metabolite

Others, Microbiology/Virology, Metabolism

191332

C30H37NO7

523.626

[H][C@]12[C@H](Cc3ccccc3)NC(=O)[C@@]11[C@H](OC(C)=O)[C@@H]3O[C@H]3[C@@](C)(O)C(=O)[C@@H](C)C\C=C\[C@@]1([H])[C@H](O)C(=C)[C@H]2C

-20°C

Ice Packs

Natural Product