α1A-AR Degrader 9c - CAS 2863635-02-1

α1A-AR Degrader 9c is a potent, selective, and reversible PROTAC degrader targeting the α1A adrenergic receptor (α1A-AR) with a DC50 of 2.86 μM. It promotes the proteasomal degradation of the α1A-AR and exhibits anti-proliferative effects against PC-3 cells, presenting an IC50 value of 6.12 μM. This compound demonstrates antitumor activity and holds potential for prostate cancer research [1].

Adrenergic Receptor, PROTACs

Neuroscience, PROTAC, GPCR/G Protein

2863635-02-1

C38H43N11O11

829.82

N(C(COCCOCCOCCN1C=C(C(=O)N2CCN(CC2)C3=NC4=C(C(N)=N3)C=C(OC)C(OC)=C4)N=N1)=O)C5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5

-20°C

Ice Packs

PROTAC