1D09C3 - CAS 791073-97-7

1D09C3 is a fully humanized anti-HLA-DR monoclonal antibody. It induces cell apoptosis (apoptosis) and death through a cascade of reactions, including reactive oxygen species (ROS) production, JNK activation, mitochondrial membrane depolarization, and the release of AIF from mitochondria. In xenograft models with JVM-2 cells and GRANTA-519 cells in mice, 1D09C3 demonstrated significant antitumor activity, improving overall survival and median survival time. This compound is applicable in cancer research, including studies on chronic lymphocytic leukemia (CLL) .

ROS, Apoptosis, JNK, MHC

Immunology/Inflammation, Apoptosis, MAPK

791073-97-7

-20°C

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Inhibitory Antibodies