(1S,2R) -Alicapistat - CAS 2221010-57-5

(1S,2R) -Alicapistat ((1S,2R) -ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, showing promise for Alzheimer's disease (AD) therapy [1]. It effectively addresses the metabolic liability associated with carbonyl reduction and demonstrates potent inhibition of calpain 1 with an IC50 value of 395 nM [2].

Cysteine Protease, Proteasome

Ubiquitination, Proteases/Proteasome

2220948

0.996

C25H27N3O4

433.5

O=C(N[C@@H](Cc1ccccc1)C(=O)C(=O)NC1CC1)[C@H]1CCC(=O)N1Cc1ccccc1

-20°C

Ice Packs

Small Compound