2,2,2-Trichloroethanol - CAS 115-20-8

2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4) . It activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery [1]. [1]. Nikhil K Parelkar, et al. 2,2,2-trichloroethanol Activates a Nonclassical Potassium Channel in Cerebrovascular Smooth Muscle and Dilates the Middle Cerebral Artery. J Pharmacol Exp Ther. 2010 Mar;332 (3) :803-10.

Potassium Channel, Endogenous Metabolite

Metabolism, Membrane transporter/Ion channel

87

0.9974

C2H3Cl3O

149.4

OCC(Cl)(Cl)Cl

-20°C

Ice Packs

Natural Product