2'2'-cGAMP (sodium salt) - CAS 1465774-27-9

2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes , which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2'2-cGAMP shows weaker binding to STING than 2'3'-cGAMP but binds more strongly than 3'3'-cGAMP , cyclic di-GMP , or 3'2'-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 μM, respectively) . Despite weaker binding, 2'2'-cGAMP induces IFN-β production in the same concentration range as 2'3'-cGAMP (EC50s = 15.8 and 19.4 nM, respectively, in L929 cells) .

Others, Endogenous Metabolite, STING, IFNAR

Others, Immunology/Inflammation, Metabolism

1465738

C20H24N10O13P2

674.417

[H][C@]12COP(O)(=O)O[C@@]3([H])[C@@H](O[C@]([H])(COP(O)(=O)O[C@@]([H])([C@@H](O1)n1cnc4c(N)ncnc14)C2O)[C@H]3O)n1cnc2c1[nH]c(N)nc2=O

-20°C

Ice Packs

Small Compound