2',3'-cGAMP - CAS 1441190-66-4

2',3'-cGAMP is an endogenous cyclic dinucleotide (CDN) produced by cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. It acts as a STING activator and ligand, inducing interferons (IFNs) via the TBK1/IRF3 pathway and pro-inflammatory factors via the NF-κB pathway.

Immunology/Inflammation related, COX, cGAS, STING, Endogenous Metabolite, IFNAR

Metabolism, Neuroscience, Immunology/Inflammation

1441120

0.9865

C20H24N10O13P2

674.41

O[C@H]1[C@@]2([C@@H](O[C@]1(COP(=O)(O)O[C@@]3([C@@](COP(=O)(O)O2)(O[C@H]([C@@H]3O)N4C=5C(N=C4)=C(N)N=CN5)[H])[H])[H])N6C7=C(N=C6)C(=O)N=C(N)N7)[H]

-20°C

Ice Packs

Natural Product