2'-β-C-Ethynyladenosine - CAS 640725-76-4

2'-β-C-Ethynyladenosine is a synthetic nucleoside analog that functions as a potent inhibitor of hepatitis C virus (HCV) replication by targeting the viral RNA-dependent RNA polymerase, NS5B; it inhibits HCV subgenomic replicon replication and NS5B-catalyzed RNA synthesis with half-maximal inhibitory concentration (IC50) values of 0.3 micromolar and 1.9 micromolar, respectively, and also demonstrates potent inhibitory activity against Leishmania RNA Virus 1 (LRV1) in species such as Leishmania guyanensis (Lgy) and Leishmania braziliensis.

Nucleoside Antimetabolite/Analog, HCV Protease

DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Proteases/Proteasome, Microbiology/Virology

640645

C12H13N5O4

291.26

C(#C)[C@]1(O)[C@@H](O[C@H](CO)[C@H]1O)N2C=3C(N=C2)=C(N)N=CN3

-20°C

Ice Packs

Small Compound