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2'-Fluoro-2'-Deoxyadenosine - CAS 64183-27-3

2'-Fluoro-2'-Deoxyadenosine - CAS 64183-27-3

MF-0012352-01

$31.68 USD
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Product Details

  • Bioactivity

    2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP) . 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors expressing E. coli PNP. 2'-Fluoro-2'-Deoxyadenosine can be used to synthesize 2'-deoxy-2'-fluoromodified oligonucleotides that can hybridize to RNA.

  • Target

    Nucleoside Antimetabolite/Analog

  • Related Pathways

    DNA Damage/DNA Repair, Cell Cycle/Checkpoint

  • CAS Number

    64183-27-3

  • Purity

    0.9995

  • Molecular Formula

    C10H12FN5O3

  • Molecular Weight

    269.23

  • SMILES

    Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1F

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound