2-Guanidinobezimidazole - CAS 5418-95-1

2-Guanidinobenzimidazole (2GBI) is a selective agonist of NLRP3, with a KD value of 1.29 μM for His-GFP-NLRP3. It directly binds to the LRR domain of NLRP3, facilitating the assembly and activation of the inflammasome. Additionally, 2-Guanidinobenzimidazole enhances antitumor immunity, inhibits tumor growth, and overcomes resistance to immune checkpoint blockade (ICB) .

NOD-like Receptor (NLR)

Immunology/Inflammation

5322

C8H9N5

175.191

N=C(N)NC1=NC=2C=CC=CC2N1

-20°C

Ice Packs

Small Compound