2-Linoleoyl Glycerol - CAS 3443-82-1

2-Arachidonoyl glycerol (2-AG), a natural endocannabinoid ligand for the CB1 receptor, was isolated from porcine brain and characterized. Its congener, 2-linoleoyl glycerol (2-LG), which has a linoleoyl group instead of an arachidonoyl group, also exists alongside 2-AG in vivo. While 2-LG exhibits low intrinsic activity, it enhances the activity of 2-AG and other endocannabinoids through an "entourage" effect, attributed to the inhibition of breakdown and reuptake pathways that typically decrease endocannabinoid levels post-release.

Others, Cannabinoid Receptor

Others, GPCR/G Protein

3443-82-1

C21H38O4

354.531

CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC(CO)CO

-20°C

Ice Packs

Small Compound