2-MeSADP - CAS 34983-48-7

2-MeSADP (2-Methylthioadenosine diphosphate; 2-Methylthio-ADP) is a potent agonist of purinergic (P2Y) receptors, displaying EC50 values of 19 nM for human P2Y13, 6.2 nM for mouse P2Y13, and 5 nM for human P2Y12. It also has pEC50 values of 8.29 for human P2Y1 and 5.75 for rat P2Y6. 2-MeSADP induces platelet aggregation and morphological changes, while inhibiting the accumulation of cyclic adenosine monophosphate in platelets in the presence of prostaglandin E1.

P2Y Receptor

Neuroscience, GPCR/G Protein

34928

C11H17N5O10P2S

473.29

O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=C(SC)N3)O[C@H](COP(OP(=O)(O)O)(=O)O)[C@H]1O

-20°C

Ice Packs

Small Compound