2-Methoxystypandrone - CAS 85122-21-0

2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎoB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins.2-Methoxystypandrone has anti-osteoclastogenic effect, could reflect the block of RANKL-induced association of TRAF6-TAK1 complexes with consequent decrease of IkappaB-mediated NF-kappaB and mitogen-activated protein kinases-mediated c-Fos activation pathways and suppression of NFATc1 and other gene expression, essential for bone resorption.

NOS, IκB/IKK, Bcl-2 Family, NF-κB, MMP, JAK, STAT, GSK-3, COX, TNF, Wnt/beta-catenin

Neuroscience, JAK/STAT signaling, Angiogenesis, Cytoskeletal Signaling, Chromatin/Epigenetic, Immunology/Inflammation, Proteases/Proteasome, Tyrosine Kinase/Adaptors, Apoptosis, Stem Cells, NF-κB, PI3K/Akt/mTOR signaling

85101

C14H12O5

260.24

COC1=CC(=O)c2c(O)c(C(C)=O)c(C)cc2C1=O

-20°C

Ice Packs

Natural Product